Our Research

I have investigated X chromosome reactivation during pluripotent reprogramming as a hallmark of human naive pluripotency and discovered chromatin modifications and trascription factors that are paramaount to reactivate Xi genes in the pluripotent and somatic context.

Publications.

Fusco C, Di Rella F, Liotti T, Colamatteo A, Ferrara AL, Gigantino V, Collina F, Esposito E, Donzelli I, Porcellini A, Feola A, Micillo T, Perna F, Garziano F, Maniscalco GT, Varricchi G, Mottola M, Zuccarelli B, De Simone B, di Bonito M, Matarese G, Accurso A, Pontillo M, Russo D, Insabato L, Cantone I *, Pezone A* and De Rosa V*. CD4+FOXP3Exon2+ regulatory T cell frequency predicts breast cancer prognosis and survival. Science Advances (in press) 2024

Li G, Liu YT, Yang F, Li M, Zhang Z, Pascual J, Wang ZK, Wei SZ, Zhao XY, Liu H, Zhao JB, Lin CT, Li JM, Li Z, Abate A, Cantone I*. Biotoxicity of Halide Perovskites in Mice. Adv Mater 2023 Sep 13:e2306860. doi: 10.1002/adma.202306860

Cantone I*. Replication Timing of Gene Loci in Different Cell Cycle Phases. Methods Mol Biol. 2023;2655:117-124. doi: 10.1007/978-1-0716-3143-0_10.

Ponti C, Nasti G, Di Girolamo D, Cantone I, Alharthi FA, Abate A. Environmental lead exposure from halide perovskites in solar cells. Trends Ecol Evol. 2022 Jan 25:S0169-5347(22)00002-7. doi: 10.1016/j.tree.2022.01.002

Spaziano A and Cantone I*. X-chromosome reactivation: a concise review. Biochem Soc Trans. 2021 Dec 17;49(6):2797-2805. doi: 10.1042/BST20210777

Credendino S, De Menna M, Cantone I, Moccia C, Esposito M, Di Guida L, De Felice M, De Vita G. FOXE1-Dependent Regulation of Macrophage Chemotaxis by Thyroid Cells In Vitro and In Vivo. Int J Mol Sci. 2021 Jul 17;22(14):7666. doi: 10.3390/ijms22147666

Credendino SC, Neumayer C & Cantone I*. Genetic and Epigenetic of Sex Bias: insights from human cancer and autoimmunity. Trends in Genetics 2020 Sep;36(9):650-663. doi: 10.1016/j.tig.2020.06.016. Review

Tagliaferri D, Mazzone P, Noviello TM, Addeo M, Angrisano T, Del Vecchio L, Visconte F, Ruggieri V, Russi S, Caivano A, Cantone I, De Felice M, Ceccarelli M, Cerulo L, Falco G. Retinoic Acid Induces Embryonic Stem Cells (ESCs) Transition to 2 Cell-Like State Through a Coordinated Expression of Dux and Duxbl1. Front. Cell Dev. Biol. 17 January 2020. doi.org/10.3389/fcell.2019.00385

Li J, Cao HL, Jiao WB, Wang Q, Wei M, Cantone I, Lü J, Abate A. Biological impact of lead from halide perovskites reveals the risk of introducing a safe threshold. Nat Commun 11, 310 (2020) doi:10.1038/s41467-019-13910-y

Cantone I*. Reversal of X chromosome inactivation: lessons from pluripotent reprogramming of mouse and human somatic cells. J Transl Genet Genom 2017;1:1-14. doi:10.20517/jtgg.2017.19. Review.

Cantone I and Fisher AG. Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease. Philos Trans R Soc Lond B Biol Sci. 2017 Nov 5;372(1733). pii: 20160358. doi: 10.1098/rstb.2016.0358. Review.

Cantone I* (corresponding author), Dharmalingam G, Chan YW, Kohler AC, Lenhard B, Merkenschlager M and Fisher AG. Allele-specific analysis of cell fusion-mediated pluripotent reprogramming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation. Genome Biol. 2017 Jan 25;18(1):2. doi: 10.1186/s13059-016-1136-4.

Cantone I, Bagci H, Dormann D, Dharmalingam G, Nesterova T, Brockdorff N, Rougeulle C, Vallot C, Heard E, Chaligne R, Merkenschlager M, Fisher AG. Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming. Nat Commun. 2016 Aug 10;7:12354. doi: 10.1038/ncomms12354.

Landeira D, Bagci H, Malinowski A, Brown KE, Soza-Ried J, Feytout A, Webster Z, Ndjetehe E, Cantone I, Asenjo HG, Brockdorff N, Carroll T, Merkenschlager M and Fisher AG. Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development. Cell Rep. 2015 Jul 28;12(4):573-86. doi: 10.1016/j.celrep.2015.06.060.

Cantone I, Fisher AG. Epigenetic programming and reprogramming during development. Nat Struct Mol Biol. 2013 Mar 5;20(3):282-9. doi: 10.1038/nsmb.2489. Review.

Tsubouchi T, Soza-Ried J, Brown K, Piccolo FM, Cantone I, Landeira D, Bagci H, Hochegger H, Merkenschlager M, Fisher AG. DNA synthesis is required for reprogramming mediated by stem cell fusion. Cell. 2013 Feb 14;152(4):873-83. doi: 10.1016/j.cell.2013.01.012.

Piccolo FM, Pereira CF, Cantone I, Brown K, Tsubouchi T, Soza-Ried J, Merkenschlager M, Fisher AG. Using heterokaryons to understand pluripotency and reprogramming. Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2260-5. doi: 10.1098/rstb.2011.0004.

Cantone I, Fisher AG. Unraveling epigenetic landscapes: the enigma of enhancers. Cell Stem Cell. 2011 Feb 4;8(2):128-9. doi: 10.1016/j.stem.2011.01.005.

Cantone I, Cosma MP, Marucci L, Sanges D. “Circuiti genici e programmabilita' della cellula”. Book Chapter (Italian), in “Biologia Sintetica”, Patron Editore.

Batt G, Page M, Cantone I, Goessler G, Monteiro P, de Jong H. Efficient parameter search for qualitative models of regulatory networks using symbolic model checking. Bioinformatics. 2010 Sep 15;26(18):i603-10. doi: 10.1093/bioinformatics/btq387.

Marucci L, Barton DA, Cantone I, Ricci MA, Cosma MP, Santini S, di Bernardo D, di Bernardo M. How to turn a genetic circuit into a synthetic tunable oscillator, or a bistable switch. PLoS One. 2009 Dec 7;4(12):e8083. doi: 10.1371/journal.pone.0008083.

Cantone I, Marucci L, Iorio F, Ricci MA, Belcastro V, Bansal M, Santini S, di Bernardo M, di Bernardo D, Cosma MP. A Yeast Synthetic Network for In Vivo Assessment of Reverse-Engineering and Modeling Approaches. Cell. 2009 Apr 3; 137 (1): 172-181. doi: 10.1016/j.cell.2009.01.055.

*corresponding author